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MessagePosté le: Sam 21 Mai - 16:20 (2016)    Sujet du message: Shams El Baroudi - ??? ???????? - ??? ??? Target= Répondre en citant




Shams El Baroudi - ??? ???????? - ??? ??? Target= > bit.ly/1Rfw89R





was...associated...with...Aurar...al-ShamTop-ranked....FFLs....that....are....common....across....the....six....cancer....data....sets....consist....of....TFs....USF1,....ARNT,....MYC,....MAX,....AHR,....CREB1....and....miRNAs....mir-15a,....miR-16,....miR-17,....miR-20a....and....miR-195....(Table1;....see....Supplementary....File....S4....for....the....complete....list)In..summary,..the..FFL..model..performs..comparably..or..better..in..identifying..top..cancer-related..miRNAs..or..TFs..compared..to..existing..approaches.FFL-based..integrative..analysis..is..more..robustWe..found..that..for..the..same..biological..process..or..disease,..results..from..the..FFL..model..are..more..comparable..between..data..sets..than..those..from..traditional..methods..such..as..differential..expression..or..TF/miRNA..target..enrichmentand....C.LIn..our..analysis,..the..expression..levels..of..most..miR-15..and..miR-17..family..members..increase..in..most..cancer..types..relative..to..normal,..and..there..is..clear..expression..correlation..in..the..miRNA..clusters..(Supplementary..File..S5)Proc[PMC....free....article]....[PubMed]35[PubMed]9McLendon...R,...Friedman...A,...Bigner...D,...Van...Meir...EG,...Brat...DJ,...Mastrogianakis...GM,...Olson...JJ,...Mikkelsen...T,...Lehman...N,...Aldape...K,...et...al[PubMed]29contributed...to...data...collectiondesigned....the....study....and....wrote....the....manuscriptRevMETHODSWe..developed..the..dChip-GemiNI..analysis..method..to..integrate..the..regulatory..network..structure..with..the..combined..gene..and..miRNA..expression..profiling..data..generated..for..two..biological..states,..such..as..normal..and..cancerIn....the....third....step,....we....compute....the....network....motif....score....(NMS)....and....the....false....discovery....rate....(FDR)....for....each....candidate....TF&#x02013;miRNA....FFLAfter...a...prolific...career...in...the...1960s,...she...came...under...spotlight...with..."transgressive"...roles...in...early...1970sPLoS...Oneis..a..scholar..of..the..Hundred..Talents..Program..of..the..Chinese..Academy..of..SciencesWe....found....that....3.2%....of....all....significant....FFLs....(FDR&#x02009;<&#x02009;0.1)....from....kidney....cancer....co-mentioned....in....at....least....one....publication,....compared....to....only....1.2%....of....all....TF&#x02013;miRNA....pairs....co-mentioned2011;39:D152D157The...plot...highlights...top...TFs...STAT1,...MYC...and...USF1...(Figure...3a)...and...top...miRNAs...miR-15a,...miR-16...and...miR-20b...(Figure...3d)...as...the...regulators...forming...FFLs...that...account...for...a...large...proportion...of...transcriptome...changes...in...kidney...cancerNatThese....miRNA....clusters....are....potentially....co-regulated....by....dozens....of....TFs....including....ARNT,....MYC....and....CREB12001;294:853858We....searched....for....TFBS....in....the....5-kb....promoter....region....upstream....of....the....transcription....start....site....(TSS)....of....RefSeq....genesProc2011;39:D1005D1010Natcontributed....to....the....biological....interpretationWe...first...assessed...the...correlation...between...TFs...and...miRNAs&#x02019;...differential...expression...ranking...and...their...occurrence...in...cancer-related...PubMed...abstractsThe..numbers..have..more..than..doubled..in..the..last..18..monthsNucleic....Acids....ResLagos-Quintana...M,...Rauhut...R,...Lendeckel...W,...Tuschl...T[PMC....free....article]....[PubMed]21USAmiRNA....clusters....and....miRNA....families....are....widely....distributed....in....the....genome:....there....are....over....200....miRNAs....forming....over....60....physical....clusters....on....chromosomes....and....over....200....miRNAs....belonging....to....approximately....100....miRNA....families f5880b0734



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